Bacteriocin-Like Inhibitory Substances from Probiotics as Therapeutic Agents for Candida Vulvovaginitis

Bacteriocins and Bacteriocin-like Substances.

Probiotics as immunomodulators: substances, mechanisms and therapeutic benefits

The human gut symbionts in whole and probiotics in particular promote intestinal function and health, partially via modulation of gut associated lymphoid tissue. Molecular basis of microbiota-host interaction is pattern recognition receptors (PRRs) and their ligands, viz., microbe-associated molecular patterns (MAMP). Immunomodulatory effects of probiotics are strain-specific, which is importan...

Bacteriocin-like substances produced by Lactococcus lactis subsp. lactis CF4MRS isolated from fish intestine: Antimicrobial activities and inhibitory properties

In the present study, evaluation of antimicrobial activities of Lactococcus lactis subsp. lactis CF4MRS bacteriocin-like substances (BLIS) against various fish pathogens was performed using an agar well diffusion assay. The cell-free supernatant (CFS) was first pre-treated using four different bioassays. In the first treatment T1, CFS was treated with catalase, and the pH was adjusted to 6.5 wi...

Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders.

Neurodegenerative disorders and diseases (NDDs) that are either chronically acquired or triggered by a singular detrimental event are a rapidly growing cause of disability and/or death. In recent times, there have been major advancements in our understanding of various neurodegenerative disease states that have revealed common pathologic features or mechanisms. The many mechanistic parallels di...

Fluconazole-resistant Candida albicans vulvovaginitis.

OBJECTIVE As a result of high recurrence rates of Candida albicans vaginitis, successful suppressive fluconazole is widely used, and drug resistance is considered rare. We report increased occurrence of secondary fluconazole resistance, analysis of risk factors thereof, and describe management of fluconazole-refractory vaginitis. METHODS Patients referred to the Vaginitis Clinic at Wayne Stat...